PUBLICACIONES

2024

Castagnini, D., Palma, K., Jara-Wilde, J., Navarro, M. N., González, M. J., Toledo, J., … & Härtel, S. (2024). Proteus mirabilis biofilm expansion microscopy yields over 4-fold magnification for super-resolution of biofilm structure and subcellular DNA organization. Journal of Microbiological Methods, 106927. https://doi.org/10.1016/j.mimet.2024.106927

Cubillos, P., Diaz, E., Báez, P., Gutiérrez, L., Molina, C., & Härtel, S. (2024). E-learning module for cytopathology education based on virtual microscopy. Journal of the American Society of Cytopathology, 13(1), 42-52.

2023

Olivera, A., PIETRASANTA, L., Kamaid, A., Miranda, K., Carvalho, H., Hartel, S., … & Casanova, G. (2023, August). Strengthening Community Governance in Latin American Bioimaging Network. In Open Infrastructure Fund/Fondo de Infraestructura Abierta. https://openreview.net/forum?id=tNpZC5mfDf

Cubillos, P., Diaz, E., Báez, P., Gutiérrez, L., Molina, C., & Härtel, S. (2023). E-Learning Module for Cytopathology Education Based on Virtual Microscopy. Journal of the American Society of Cytopathology. https://doi.org/10.1016/j.jasc.2023.10.002

Lobos, P., Vega-Vásquez, I., Bruna, B., Gleitze, S., Toledo, J., Härtel, S., … & Paula-Lima, A. (2023). Amyloid β-Oligomers Inhibit the Nuclear Ca2+ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons. Antioxidants, 12(11), 1972. https://doi.org/10.20944/preprints202310.0984.v1

Gatica, M., Navarro, C. F., Lavado, A., Reig, G., Pulgar, E., Llanos, P., Härtel, S., … & Cerda, M. (2023). VolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks. BMC bioinformatics, 24(1), 1-7. https://doi.org/10.1186/s12859-023-05403-z

Miranda Ruiz, F., Lahrmann, B., Bartels, L., Krauthoff, A., Keil, A., Tao, A. S., Härtel, S., … & Grabe, N. (2023). CNN Stability Training improves robustness to scanner and IHC-based image variability for epithelium segmentation in cervical histology. Frontiers in Medicine, 10, 1173616. 10.3389/fmed.2023.1173616

Härtel S., Molina M., Campos R., Carvajal A., Salinas A., Bravo F., Agudelo MF., González E., Ramírez T., Cardona M., Cáceres S., Castro P., Ulloa V., López J., Guiñez S., Coñuecar S., Arancibia C. Universidad de Chile. Diagnóstico Integral para el Desarrollo de Competencias en Salud Digital en la Red de Salud Digital de Universidades del Estado RSDUE

P. Scavone, V. Iribarnegaray, M.J. González, N. Navarro, N. Canales-Huerta, J. Jara-Wilde, S. Härtel, P. Zunino. (2023). Role of Proteus mirabilis flagella in biofilm formation, Revista Argentina de Microbiología, https://doi.org/10.1016/j.ram.2023.01.005

2022

Palma, K., Signore, I. A., Meynard, M. M., Ibarra, J., Armijo-Weingart, L., Cayuleo, M., … & Concha, M. L. (2022). Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus. Frontiers in Cell and Developmental Biology, 10.
10.3389/fcell.2022.999265

Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., … & Posada‐Duque, R. (2022). Gliovascular alterations in sporadic and familial Alzheimer’s disease: APOE3 Christchurch homozygote glioprotection. Brain Pathology, e13119.
https://doi.org/10.1111/bpa.13119

Araos R, Basso L, Bravo L, Escobar MJ, Etcheverry A, Härtel S, Hermosilla MP, Jara A, Maass A, Marquet P and Pérez-Acle T (2022). Datos de interés público para informar, tomar decisiones y crear conocimiento. Comité Asesor Ministerial de Datos de Interés Público – MinCiencia
https://datos.minciencia.gob.cl/#/documentos

de los Ángeles Juricic Urzúa, M., Gallardo Rojas, J., Couve Correa, A., Cerda, M., Härtel Gründler, S., & González‐Silva, C. The Dendritic Ergic: Microtubule And Actin Cytoskeletons Participate In Stop‐And‐Go Movement Of Mobile Carriers Between Stable Structures. Traffic.
https://doi.org/10.1111/tra.12832

2021

Ulloa, R., Corrales, O., Cabrera-Reyes, F., Jara-Wilde, J., Sáez, J. J., Rivas, C., … & Díaz Muñoz, J. B cells adapt their nuclear morphology to organize the immune synapse and facilitate antigen extraction. Frontiers in Immunology, 5916.
https://doi.org/10.3389/fimmu.2021.801164

Álvarez Román, F.; Araya Saldivar, L.; Varas Rocco, M.; Arribada Maldonado, A.,….Lampert Grassi, MP. (2021). Mesa técnica “Fondo de salud extraordinario : Propuestas de Universidades, Sociedades Científicas y Colegios Profesionales”. Biblioteca del Congreso Nacional de Chile, pp. 245-263.
https://www.bcn.cl/catalogo/detalle_libro2?bib=278678&k=OTg2Ozk9PDY6NWM2Ozw6Ozw=

Lobos, P., Córdova, A., Vega-Vásquez, I., Ramírez, O. A., Adasme, T., Toledo, J., … & Hidalgo, C. (2021). RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 expression. Proceedings of the National Academy of Sciences, 118(33).
https://doi.org/10.1073/pnas.2102265118

Pulgar E., Schwayer C., Guerrero N., López L., Márquez S, Härtel S., Soto R., Heisenberg CP. And ML Concha (2021). Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLife 10:e66483
https://doi.org/10.7554/eLife.66483

Sotomayor C., Mendoza M., Castañeda V., Farías H., Molina G., Pereira G., Härtel S., Solar M., Araya M. (2021). Content‐Based Medical Image Retrieval and Intelligent Interactive Visual Browser for Medical Education, Research and Care. Diagnostics 2021, 11, 1470.
https://doi.org/10.3390/diagnostics11081470

Lecaros, C., Dunstan, J., Villena, F., Ashcroft, D. M., Parisi, R., Griffiths, C. E. M., … & De la Cruz, C. (2021). The incidence of psoriasis in Chile: an analysis of the national Waiting List Repository. Clinical and Experimental Dermatology.
https://doi.org/10.1111/ced.14713

Mónaco, A., Canales-Huerta, N., Jara-Wilde, J., Härtel, S., Chabalgoity, J. A., Moreno, M., & Scavone, P. (2021). Salmonella Typhimurium triggers Extracellular Traps release in murine macrophages. Frontiers in cellular and infection microbiology, 11.
https://doi.org/10.3389/fcimb.2021.639768

Ramírez, O. A., Córdova, A., Cerda, M., Lobos, P., Härtel, S., Couve, A., & Hidalgo, C. (2021). Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons. Cell Calcium, 96, 102399.
https://doi.org/10.1016/j.ceca.2021.102399

Alhashem, Z., Portillo, M. A. G., Htun, M. R., Gauert, A., Montecinos, L. B., Härtel, S., & Linker, C. (2021). Zebrafish Neural Crest: Lessons and Tools to Study In Vivo Cell Migration. In The Epithelial-to Mesenchymal Transition (pp. 79-106). Humana, New York, NY.
https://doi.org/10.1007/978-1-0716-0779-4_9

Swedlow, J.R., Kankaanpää, P., Sarkans, U. et al. A global view of standards for open image data formats and repositories. Nat Methods (2021).
https://doi.org/10.1038/s41592-021-01113-7

2020

Sigle, S., Barriga, P., Fernández, F. J. C., Juhra, C., Härtel, S., & Fegeler, C. (2020). Evaluating Online Consumer Medication Information Systems: Comparative Online Usability Study. JMIR mHealth and uHealth, 8(6), e16648.

Arancibia D, Araos R, Basso L, Bravo L, Guridi J, Härtel S, Jara J, Maass A, Marquet P, Mora S and Pérez-Acle T. (2020) Una mirada a la cultura de datos en Chile – Desafíos y Lecciones de la Pandemia por COVID-19. Submesa de Datos Covid-19 – MinCiencia.
https://www.minciencia.gob.cl/legacy-files/whitepaper_datos_covid19.pdf

Frigerio, S., Da Costa, V., Costa, M., Festari, M. F., Landeira, M., Rodríguez-Zraquia, S. A., … & Freire, T. (2020). Eosinophils Control Liver Damage by Modulating Immune Responses Against Fasciola hepatica. Frontiers in Immunology, 11, 2276.
https://doi.org/10.3389/fimmu.2020.579801

Cueva, E., Courdurier, M., Osses, A., Castañeda, V., Palacios, B., & Härtel, S. (2020). Mathematical modeling for 2D light-sheet fluorescence microscopy image reconstruction. Inverse Problems, 36(7), 075005.
https://doi.org/10.1088/1361-6420/ab80d8

Jara‐Wilde J, Castro I, Lemus Carmen Gloria, Palma Karina, Valdés Francisca, Castañeda Víctor, Hitschfeld Nancy, Concha Miguel L and Steffen Hartel (2020).Optimising adjacent membrane segmentation and parameterisation in multi‐cellular aggregates by piecewise active contours. Journal of Microscopy 278(2):59-75
https://doi.org/10.1111/jmi.12887

Liddle, P., Jara-Wilde, J., Lafon-Hughes, L., Castro, I., Härtel, S., & Folle, G. (2020). dSTORM microscopy evidences in HeLa cells clustered and scattered γH2AX nanofoci sensitive to ATM, DNA-PK, and ATR kinase inhibitors. Molecular and Cellular Biochemistry, 473(1), 77-91.
https://doi.org/10.1007/s11010-020-03809-4

2019

Ampuero, E., Cerda, M., Härtel, S., Rubio, F. J., Massa, S., Cubillos, P., … & Wyneken, U. (2019). Chronic fluoxetine treatment induces maturation-compatible changes in the dendritic arbor and in synaptic responses in the auditory cortex. Frontiers in pharmacology, 10, 804.
https://doi.org/10.3389/fphar.2019.00804

2018

Gonzalez A, Hartel S, Mansilla J, Sanchez-Valdez F and A. Ferreira (2018) Variable numbers of calcereticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression. Immunobiology 223;12:802-806.
http://dx.doi.org/10.1016/j.imbio.2018.08.005

2017

Chang, V., Garcia, A., Hitschfeld, N., & Härtel, S. (2017). Gold-standard for computer-assisted morphological sperm analysis. Computers in biology and medicine, 83, 143-150.
https://doi.org/10.1016/j.compbiomed.2017.03.004

Pereiro, L., Loosli, F., Fernández, J., Härtel, S., Wittbrodt, J., & Concha, M. L. (2017). Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias. Developmental Dynamics, 246(11), 812-826.
https://doi.org/10.1002/dvdy.24496

SanMartín, C. D., Veloso, P., Adasme, T., Lobos, P., Bruna, B., Galaz, J., … & Paula-Lima, A. C. (2017). RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid β peptide oligomers. Frontiers in molecular neuroscience, 10, 115.
https://doi.org/10.3389/fnmol.2017.00115

Chang, V., Heutte, L., Petitjean, C., Härtel, S., & Hitschfeld, N. (2017). Automatic classification of human sperm head morphology. Computers in biology and medicine, 84, 205-216.
https://doi.org/10.1016/j.compbiomed.2017.03.029

Reig, G., Cerda, M., Sepúlveda, N., Flores, D., Castañeda, V., Tada, M., … & Concha, M. L. (2017). Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish. Nature communications, 8(1), 1-14.
https://doi.org/10.1038/ncomms15431

Lemus C, Palma K, Jara J, Härtel S and M Concha (2017) Asymmetric Morphogenesis of the Parapineal Organ in the Embryonic Zebrafish Brain. Mechanisms of Development, 145:S56. doi:10.1016/j.mod.2017.04.112.
https://doi.org/10.1016/j.mod.2017.04.112

Bustos, F. J., Ampuero, E., Jury, N., Aguilar, R., Falahi, F., Toledo, J., … & Van Zundert, B. (2017). Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice. Brain, 140(12), 3252-3268.
https://doi.org/10.1093/brain/awx272

Palma, K., Meynard, M., Cornejo, V., Cerda, M., Jara, J., Härtel, S., & Concha, M. (2017). Light/dark cycles modulate asymmetric parapineal connectivity to the left habenula in zebrafish larvae. Mechanisms of Development, (145), S122-S123.
https://doi.org/10.1016/j.mod.2017.04.334

Posada-Duque, R. A., Ramirez, O., Härtel, S., Inestrosa, N. C., Bodaleo, F., González-Billault, C., … & Cardona-Gómez, G. P. (2017). CDK5 downregulation enhances synaptic plasticity. Cellular and Molecular Life Sciences, 74(1), 153-172.
https://doi.org/10.1007/s00018-016-2333-8

Laliena A, Castañeda V, Härtel S and M Concha (2017) Sleep/wake disorders and the hypocretin/orexin system in a zebrafish model of Parkinson’s Disease. Mechanisms of Development; 145:S128
https://doi.org/10.1016/j.mod.2017.04.352

Rojas-Moraleda, R., Valous, N. A., Gowen, A., Esquerre, C., Härtel, S., Salinas, L., & O’Donnell, C. (2017). A frame-based ANN for classification of hyperspectral images: assessment of mechanical damage in mushrooms. Neural Computing and Applications, 28(1), 969-981.
https://doi.org/10.1007/s00521-016-2376-7

González, A., Härtel, S., Mansilla, J., Sánchez-Valdéz, F., & Ferreira, A. (2018). Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression. Immunobiology, 223(12), 802-806.
https://doi.org/10.1016/j.imbio.2018.08.005

Capurro, D., Echeverry, A., Figueroa, R., Guiñez, S., Taramasco, C., Galindo, C., … & Hartel, S. (2017). Chile’s national center for health information systems: A public-private partnership to foster health care information interoperability.
doi:10.3233/978-1-61499-830-3-693

Marquez, S., Soto, R., Pulgar, E., Concha, M., & Hartel, S. (2017, July). Physical Model of Collective Cell Migration in Zebrafish Gastrulation. In EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Vol. 46, pp. S274-S274). 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.
ISSN: 0175-7571 eISSN:1432-1017

Ahumada-Galleguillos, P., Lemus, C. G., Díaz, E., Osorio-Reich, M., Härtel, S., & Concha, M. L. (2017). Directional asymmetry in the volume of the human habenula. Brain Structure and Function, 222(2), 1087-1092.
https://doi.org/10.1007/s00429-016-1231-z

Maldonado, H., Calderon, C., Burgos-Bravo, F., Kobler, O., Zuschratter, W., Ramirez, O., … & Leyton, L. (2017). Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1864(2), 243-254.
https://doi.org/10.1016/j.bbamcr.2016.11.006

2016

Scavone, P., Iribarnegaray, V., Caetano, A. L., Schlapp, G., Härtel, S., & Zunino, P. (2016). Fimbriae have distinguishable roles in Proteus mirabilis biofilm formation. Pathogens and disease, 74(5).
https://doi.org/10.1093/femspd/ftw033

Richardson, J., Gauert, A., Montecinos, L. B., Fanlo, L., Alhashem, Z. M., Assar, R., … & Linker, C. (2016). Leader cells define directionality of trunk, but not cranial, neural crest cell migration. Cell reports, 15(9), 2076-2088.
https://doi.org/10.1016/j.celrep.2016.04.067

Ampuero E, Jury N, Härtel S, Marzolo MP and B van Zundert (2016) Interfering of the reelin/ApoER2/PSD95 signaling axis reactivates structural plasticity of mature hippocampal neurons. Journal of Cellular Physiology, 232(5):1187-1199.
https://doi.org/10.1002/jcp.25605

Pezoa, R., Salinas, L., Torres, C., Härtel, S., Maureira-Fredes, C., & Arce, P. (2016, October). Segmentation of HER2 protein overexpression in immunohistochemically stained breast cancer images using Support Vector Machines. In Journal of Physics: Conference Series (Vol. 762, No. 1, p. 012050). IOP Publishing.
https://doi.org/10.1088/1742-6596/762/1/012050

2015

González A, Valck C, Sanchez G, Härtel S, Mansilla J, Ramirez G, Fernandez S, Arias JL, Galanti N and A Ferreira (2015) Trypanosoma cruzi Calreticulin Topographic Variations in Parasites Infecting Murine Macrophages. Journal of Tropical Medicine and Hygiene, 92 (5):887-897.
https://doi.org/10.4269/ajtmh.14-0497

Liempi A, Castillo C, Cerda M, Droguett D, Duaso J, Barahona K, Hernández A, Díaz-Luján C, Fretes R, S Härtel and U Kemmerling (2015) Trypanosoma cruzi Infectivity Assessment in ‘in vitro’ Culture Systems by Automated Cell Counting. Acta Tropica, 143:47-50.
https://doi.org/10.1016/j.actatropica.2014.12.006

Maturana J, Niechi I, Silva-Pavez E, Huerta-Castro H, Cataldo R, Härtel S, Barros F, Galindo M and J Tapia (2015) Transactivation activity and nucleocytoplasmic transport of β-catenin are independently regulated by its C-terminal end. GENE, 573 (1): 115-22. DOI: 10.1016/j.gene.2015.07.039

Jara-Wilde J, Cerda M, Delpiano J and S Härtel (2015) An Implementation of Combined Local- Global Optical Flow. Image Processing On Line, 5:139–158.
http://dx.doi.org/10.5201/ipol.2015.44

Maturana-Ramírez, A., Espinoza, I., Reyes, M., Aitken, J. P., Aguayo, F., Hartel, S., & Rojas-Alcayaga, G. (2015). Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma. International journal of clinical and experimental pathology, 8(10), 13677.
doi:10.1126/scitranslmed.aad5859

2014

San Martín CD, Paula-Lima AC, García A, Härtel S, Núñez MT and C Hidalgo C (2014) Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons. Frontiers in Molecular Neuroscience, 7-13. doi: 10.3389/fnmol.2014.00013.
http://dx.doi.org/10.3389/fnmol.2014.00013

Busso D, Oñate-Alvarado MJ, Balboa E, Castro J, Lizama C, Morales G, Vargas S, Härtel S, Moreno RD and S Zanlungo (2014) Spermatozoa from mice deficient in Niemann- Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability. Reproduction, Fertility and Development, 26(4):609-621.
doi: 10.1071/RD12059

Castañeda V, Cerda M, Santibañez F, Jara J, Pulgar E, Palma K, Lemus CG, Concha M and S Hartel. Computational Methods for Analysis of Dynamic Events In Cell Migration. Current Molecular Medicine, 14 (2):291-307.
https://doi.org/10.2174/1566524014666140128113952

Chang V, Saavedra J, Castañeda V, Sarabia L, Hitschfeld N and S Härtel (2014) Gold- standard and improved framework for sperm head segmentation. Computer Methods and Programs in Biomedicine, 117 (2):225-237.
http://dx.doi.org/10.1016/j.cmpb.2014.06.018

Liddle P, Lafon-Hughes L, Di Tomaso MV, Reyes-Ábalos AL, Jara J, Cerda M, Härtel S and G Folle (2014) Bleomycin-induced γH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei. Chromosome Research,22 (4):463-481. doi: 10.1007/s10577-014-9433-9.
http://dx.doi.org/10.1007/s10577-014-9433-9

2013

Bodaleo, F., Montenegro-Venegas, C., Court, F., Hartel, S., & Gonzalez-Billault, C. (2013, January). Microtubule-associated protein 1B (MAP1B) regulates synaptic functions in mature neurons. In MOLECULAR BIOLOGY OF THE CELL (Vol. 24). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
doi: 10.1074/jbc.M111.271320

Castillo, C., Liempi, A., Droguett, D., Duaso, J., Cerda, M., Härtel, S., … & Kemmerling, U. (2013). Trypanosoma cruzi induces differentiation of the trophoblast. Placenta, 9(34), A78.
https://doi.org/10.1016/j.placenta.2013.06.230

Droguett D, Liempi A, Castillo C, Duaso J, Cerda M, Härtel S, Galanti N, Maya JD and U Kemerling (2013) Trypanosoma Cruzi Induces Cellular Proliferation in the Trophoblastic Cell Line Bewo. Placenta; 34 (9):A78
http://dx.doi.org/10.1016/j.placenta.2013.06.231

Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, Guerrero N, Meynard M, Pérez R, Suazo J, Marcelain-Cubillos K, Briones L, Härtel S, Wilson S and M Concha (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development, 140:3997-4007.
http://dx.doi.org/10.1242/dev.091934

Huss A, Ramírez O, Santibáñez F, Couve A, Härtel S and J Enderlein (2013) SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly. Proc. SPIE 8590, Single Molecule Spectroscopy and Superresolution Imaging VI, 85900N. doi:10.1117/12.2006215.
http://dx.doi.org/10.1117/12.2006215

2012

Husen P, Fidorra M, Härtel S, Bagatolli L and J Ipsen (2012) A Method for Analysis of Lipid Vesicle Domain Structure from Confocal Image Data. European Biophysics Journal (EBJO), 41(2):161-75.
DOI 10.1007/s00249-011-0768-2

Urra H, Torres V, Ortiz R, Lobos L, Díaz M, Díaz N, Härtel S, Leyton L and A Quest (2012) Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but not Accumulation to the Rear in Metastatic Cancer Cells. PLosOne, 7 (4):e33085, 1-14.
http://dx.doi.org/10.1371/journal.pone.0033085

Delpiano, J., Jara, J., Scheer, J., Ramírez, O. A., Ruiz-del-Solar, J., & Härtel, S. (2012). Performance of optical flow techniques for motion analysis of fluorescent point signals in confocal microscopy. Machine Vision and Applications, 23(4), 675-689.
http://dx.doi.org/10.1007/s00138-011-0362-8

Astorga G, Härtel S, Sanhueza M and J Bacigalupo (2012) TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in axonal terminals of Drosophila photoreceptors. PLosOne, 7(8):e44182. doi:10.1371/ journal.pone.0044182.
http://dx.doi.org/10.1371/journal.pone.0044182

Hitschfeld N, Härtel S, Jara J, Lemus CG, Santibañez F, Ramirez O and M Concha (2012) Ciencia computacional aplicada a la biomedicina. Revista BITS de Ciencia Universidad de Chile. FCFM, 36-43.

2011

Riquelme D, Alvarez A, Leal N, Adasme T, Espinoza I, Valdés JA, Troncoso N, Härtel S, Hidalgo J, Hidalgo C and MA Carrasco (2011) High-frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-mediated Ca2+ Release and Generates Hydrogen Peroxide, which Jointly Stimulate NF-kB Activity. Antioxid Redox Signal, 14(7): 1245-59.
doi: 10.1089=ars.2010.3238

Ramirez O, Härtel S, Couve A (2011) Location matters: the endoplasmic reticulum and protein trafficking in dendrites. Biological Reseach, 44:17-23.
http://dx.doi.org/10.4067/S0716-97602011000100003

Horta F, Madariaga M, Garcia A, Härtel S and R Smith (2011) Association of age with sperm DNA fragmentation / Aumento del daño en el DNA espermatico en varones mayores de 40 años. Revista Médica de Chile, 139:306-312.
http://dx.doi.org/10.4067/S0034-98872011000300004

Bahamondes V, Albornoz M, Aguilera S, Alliende C, Molina C , Castro I, Urzua U, Quest A, Barrera M, González S, Sanchez M, Härtel S, Hermoso M, Leyton C and M González (2011) Changes in Rab3D expression and distribution in acini of Sjögren’s Syndrome patients is associated to loss of cell polarity and secretory dysfunction. Arthritis & Rheumatism, 63(10): 3126-3135.
http://dx.doi.org/10.1002/art.30500

Schlapp G, Scavone P, Zunino P and S Härtel (2011) Development of 3D Architecture of Uropathogenic Proteus mirabilis Batch Culture Biofilms – A Quantitative Confocal Microscopy Approach. J Microbiol Methods, 87(2): 234-40.
http://dx.doi.org/10.1016/j.mimet.2011.07.021

Tortosa, E., Montenegro-Venegas, C., Benoist, M., Härtel, S., González-Billault, C., Esteban, J. A., & Avila, J. (2011). Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation. Journal of Biological Chemistry, 286(47), 40638-40648.
https://doi.org/10.1074/jbc.M111.271320

2010

Cárdenas C, Escobar M, García A, Osorio-Reich M, Härtel S, Foskett JK and C Franzini- Armstrong (2010) Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by deep etching electron microscopy. J Struct Biol, 171 (3):372-381.
doi:10.1016/j.jsb.2010.05.003

Oteiza P, Koeppen M, Krieg M, Pulgar E, Farias C, Melo C, Preibisch S, Müller D, Tada M, Hartel S, Heisenberg CP and M Concha (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development, 137: 3459-68.
doi:10.1242/dev.049981

Fanani ML, Härtel S, De Tullio L, Jara J, Olmos F, Oliveira R and B Maggio (2010) The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis. Biochimica et Biophysica Acta (BBA), 1798(7):1309-1323.
http://dx.doi.org/10.1016/j.bbamem.2010.01.001

Ramirez O, García A, Rojas R, Couve A and S Härtel (2010) Confined Displacement Algorithm Determines True and Random Colocalization in Fluorescence Microscopy. Journal of Microscopy, 239(3):173-83.
doi: 10.1111/j.1365-2818.2010.03369.x

2009

Oteiza P, Lemus C, Koppen M, Palma K, Krieg M, Melo C, Farias C, Pulgar E, Preibisch S, Hartel S, Heisenberg CP and M Concha (2009) Linking organ formation to left-right pattering in the embryonic zebrafish. Mechanisms of Development; 126(1):S11.
https://doi.org/10.1016/j.mod.2009.06.970

Reig G, Härtel S and M Concha (2009) Comparative Analysis of Epiboly in teleost fish. Mechanisms of Develpment; 126 (1):S308
https://doi.org/10.1016/j.mod.2009.06.844

Oteiza P, Koeppen M, Krieg M, Preibisch S, Haertel S, Mueller D, Heisenber CP and M Concha (2009) 03-P045 Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces. Mechanisms of Development; 126 (1):S80.
https://doi.org/10.1016/j.mod.2009.06.098

Espinosa A, Garcia A, Härtel S, Hidalgo C and E Jaimovich (2009) NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells. JBC, 284:2568-2575.
http://dx.doi.org/10.1074/jbc.M804249200

Fanani ML, De Tullio L, Härtel S, Jara J and B Maggio (2009) Sphingomyelinase- Induced Domain Shape Relaxation driven by out-of-equilibrium Changes of Composition. Biophysical Journal, 96(1):67–76. doi: 10.1529/biophysj.108.141499.
https://doi.org/10.1529/biophysj.108.141499

Ramirez O, Vidal R, Tello J, Vargas K, Kindler S, Härtel S and A Couve (2009) Dendritic Assembly of Heteromeric Gabab Receptor Subunits in Hippocampal Neurons. J Biol Chem, 284(19):13077-85. doi: 10.1074/jbc.M900575200.
http://dx.doi.org/10.1074/jbc.M900575200

Eisner V, García A, Härtel S, Escobar M, Casas M, Aedo P, Mears D, Ezquer M, Conget P, Lavandero S, Hidalgo C and E Jaimovich (2009) Insulin resistant skeletal muschle: Mitochondria structure, dynamics and calcium homeostasis. Biophysical Journal; 96(3):235a.
10.1016/j.bpj.2008.12.1157

Fidorra M, Garcia A, Ipsen J, Härtel S and L Bagatolli (2009) Lipid domains in giant unilamellar vesicles and their correspondence with equilibrium thermodynamic phases: A quantitative fluorescence microscopy imaging approach. Biochimica et Biophysica Acta (BBA) – Biomembranes, 1788(10):2142-9.
https://doi.org/10.1016/j.bbamem.2009.08.006

2008

Sánchez G, Escobar M, Pedrozo Z, Macho P, Domenech R, Härtel S, Hidalgo C and P Donoso (2008) Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection. Cardiovasc Res, 77(2):380-6
https://doi.org/10.1093/cvr/cvm011

Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C and S Lavandero (2008) Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res. 77(2):387-97.
https://doi.org/10.1093/cvr/cvm029

2007

Härtel, S., Jara, J., Lemus, C. G., & Concha, M. L. (2018). 3D morpho-topological analysis of asymmetric neuronal morphogenesis in developing zebrafish. In Computational Modelling of Objects Represented in Images (pp. 215-220). CRC Press.
Book Chapter

De Tullio L, Maggio B, Härtel S, Jara J and ML Fanani (2007) The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers. Cell Biochemistry and Biophysics, 47 (2):169-177.
doi:10.1007/s12013-007-0001-1

Lemus CG, Hartel S, Regan J, Russel C, Wilson S and M Concha (2007) Asymmetric morphogenesis of the parapineal organ in the developing zebrafish brain. Developmental Biology; 306(1):302.
http://dx.doi.org/10.1016/j.ydbio.2007.03.085

Vidal RL, Ramírez O, Sandoval L, Koenig-Robert R, Härtel S and A Couve (2007) Marlin- 1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. Molecular and Cellular Neuroscience, 35(3):501-12.
http://doi.org/10.1016/j.mcn.2007.04.008

2006

Castro J, Ruminot I, Porras OH, Flores CM, Hermosilla T, Verdugo E, Venegas F, Härtel S, Michea L and LF Barros (2006) ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload. Cell Death & Differentiation, 13:1675–85.
doi:10.1038/sj.cdd.4401852

Alvarez M, Godoy R, Gieseke A and S Härtel (2006) Surface-bound phosphatase Activity in Ectomycorrhizal Fungi: A Comparative Study Between a Colorimetric and a Microscope-Based Method. Biology & Fertility of Soils, 42(6):561-568.
doi: 10.1007/s00374-005-0053-6

2005

Härtel, S., Rojas, R., Räth, C., Guarda, M. I., & Goicoechea, O. (2005). Di-and triploid erythrocyte identification by multi-parameter image analysis: A new method for the quantification of triploidization rates in rainbow trout (Oncorhynchus mykiss). Archivos de Medicina Veterinaria, 37(2), 147-154.
http://dx.doi.org/10.4067/S0301-732X2005000200009

Alvarez M, Godoy R, Heyser W and S Härtel (2005) Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhizal of Nothofagus obliqua based on image processed confocal fluorescence microscopy. Soil Biology and Biochemistry, 37(1):125-132.
doi:10.1016/j.soilbio.2004.07.028

Härtel S, Fanani ML and B Maggio (2005) Shape Transitions and Lattice Structuring of Ceramide-Enriched Domains Generated by Sphingomyelinase in Lipid Monolayers. Biophysical Journal 88(1):287-304.
http://doi.org/10.1529/biophysj.104.048959

2004

Ojeda F, Guarda MI, Lovengreen C, Hidalgo A, Folch H, Härtel S and C Maldonado (2004) Ultraviolet exposure of thymocytes: wavelength selective inhibition and induction of apoptosis. International Journal of Radiation Biology, 80(6):445-450.
doi: 10.1080/09553000410001702328

Alvarez M, Godoy R, Heyser W and S Härtel (2004) Surface bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua. Mycologia, 96(3):479 – 487.
http://dx.doi.org/10.1080/15572536.2005.11832947

2003

Alvarez M, Härtel S, Godoy R and W Heyser (2003) New Perspectives in the Determination of phoshatase activity in ectomycorrhizal of Nothofagus obliqua in forests of southern Chile. Gayana, 60(1):41-46.
http://dx.doi.org/10.4067/S0717-66432003000100007

Carrer D, Härtel S, Maggio B and H Mónaco (2003). Ceramide Modulates the Lipid Membrane Organization at Molecular and Supramolecular Levels. Chemisty and Physics of Lipids, 122 (1-2):147-152.
http://doi.org/10.1016/S0009-3084(02)00185-8

Härtel S, Zorn-Kruppa M, Tykhonova S, Alajuuma P, Engelke M and H Diehl H (2003). Staurosporine-Induced Apoptosis in Human Cornea Epithelial Cells In Vitro. Cytometry, 08:15-23.
doi: 10.1002/cyto.a.10068

2003

2002

Jessel R, Hartel S, Socaciu C, Tykhonova S and H Diehl (2002) Kinetics of apoptotic markers in exogenously induced apoptosis of EL4 cells. Journal of Cellular and Molecular Medicine 6(1):82-92.
doi: 10.1111/j.1582-4934.2002.tb00313.x

Fanani M, Härtel S, Oliveira R and B Maggio (2002) Bidirectional Control of Sphingomyelinase Activity and Surface Topography in Lipid Monolayers. Biophysical Journal, 83(6):3416-3424
https://dx.doi.org/10.1016%2FS0006-3495(02)75341-1

Härtel S, Tykhonova S, Haas M and H Diehl (2002). The Susceptibility of Non-UV Fluorescent Membrane Dyes to Dynamical Properties of Lipid Membranes. Journal of Fluorescence, 12 (314):465-479.
doi: 10.1023/A:1021326329336

2000

Socaciu C, Jessel R, Härtel S and H Diehl (2000) Carotenoids in 1,2-dipalmitoyl-sn- glycero-3-phosphoryl-choline liposomes: incorporation and effects on phase transition and vesicle size. Journal of Medical Biochemistry 4(2):71-82.

1998

Härtel S, Ojeda F and H Diehl (1998) Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes. International Journal of Radiation Biology, 74(5):607-615.

Härtel S, Diehl H and F Ojeda (1998) Methyl-b-Cyclodextrins and Liposomes as Water- Soluble Carriers for Cholesterol Incorporation into Membranes and Its Evaluation by a Microenzymatic Fluorescence Assay and Membrane Fluidity-Sensitive Dyes. Analytical Biochemistry, 258(2):277-284.
https://doi.org/10.1006/abio.1998.2594

1998

1996

Härtel, S., & Diehl, H. A. (1996). Radiation induced membrane effects in thymocyte apoptosis. Progress in Biophysics and Molecular Biology, (65), 89.